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杨小龙 研究员 课题组
2016-03-21 09:48   审核人:


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        杨小龙  研究员

       邮箱:yxl19830915@cqu.edu.cn

                          yxl19830915@163.com



教育及工作经历

2016/2~至今

腾讯时时彩玩法说明,创新药物研究中心,重庆大学百人计划特聘研究员(博士生导师)

2009/9~2016/1

河北大学药学院,副教授(硕士生导师)

2014/5-2015/5

德国莱布尼茨汉诺威大学,博士后,导师:Prof. Russell J. Cox

2012/4-2014/4

日本东京大学,日本学术振兴会(JSPS)外国特别研究员(博士后),导师:Prof. Ikuro Abe

2004/9-2009/7

中科院昆明植物研究所,理学博士,师从刘吉开教授

2000/9-2004/7

西北农林科技大学,理学学士 

 

研究领域

1、多种研究策略驱动的药用植物内生真菌中药用活性物质生物合成潜能的挖掘及其生物功能评价。

2、真菌源药用活性天然产物代谢调控及合成生物学研究。

3、中药药效物质基础研究及相关产品开发。

4、新型抗生素和天然农药的发现及相关产品开发。


主持或参与科研项目

1横向课题:合同经费100万,执行期:20165-201712月,在研,主持。

2重庆大学百人计划启动项目(100万元,执行期:2016~2019),在研,主持。

3国家自然科学青年基金项目(21202033),拟盘多毛孢内生真菌中抗肿瘤活性先导化合物的发现及活性评价,2013/01-2015/1225万,已结题,主持。

4河北省自然科学基金项目(C2012201047),特殊生境真菌中结构新奇化学成分的发现及抗真菌活性研究,2012/01-2015/013万,已结题,主持。

5国家自然科学基金面上项目(31171885),虫生真菌中新奇结构的农药活性源头分子发现及活性评价,2012/01-2015/1266万,已结题、第一参加人。

6日本振兴学会项目(P12032),基于宏基因组学的活性物质、基因及酶的发现,2012/04-2014/04300万日元,已结题,主持。

7教育部长江学者和创新团队发展计划,新型抗肿瘤活性分子的发现及其作用机制的研究,2012~2014300万元,已结题,主要参加人。

8河北省巨人计划高层次创新团队创业团队2012/01~2013/12100万,已结题,主要参加人。

9国家自然科学基金面上项目(31071701),高等真菌中咔林类生物碱Flazin结构修饰、杀虫活性及构效关系研究,2011/01-2013/1233万,已结题,第二参加人。

10河北大学人才引进项目(179),植物内生真菌中次生代谢产物研究,2009/12-2012/126万,已结题,主持。

11国家自然科学基金重点项目(30830113),高等真菌中新型天然药物先导化合物的发现及其结构与功能,2009.01-2011.12250万,已结题,第三参加人。

12国家自然科学基金面上项目(30671385),从高等真菌中寻找新的农用抗真菌活性物质研究、2007/01-2009/1227万,已结题,第一参加人。

 

获奖及荣誉

2015:  获得重庆大学“百人计划”学者

2012:   获得日本振兴学会外国特别研究员

2008:   获得中国科学院朱李月华优秀博士奖学金

2006:   获得中国科学院西部学子一等奖学金

2006-2008:  连续3次获得中国科学院优秀三好学生

2004: 获得西北农林科技大学优秀毕业生称号

2001-2004:  连续3获得西北农林科技大学优秀三好学生称号

 

主要代表性论文

[1] Dan Xu, Ming-He Luo, Feng-Lou Liu, Dong Wang, Xue-Jiao Pang, Ting Zhao, Lu-Lin Xu, Xia Wu, Ming-Yu Xia*, Xiao-Long Yang*. Cytochalasan and tyrosine-derived alkaloids from the marine sediment-derived fungus Westerdykella dispersa and their bioactivities. Scientific Reports, 2017, 7:11956-11964. (IF = 4.259, 2)

[2] Xia Wu,  Li-Zhen Fang, Feng-Lou Liu, Xue-Jiao Pang, Hai-Li Qin, Ting Zhao, Lu-Lin Xu, Deng-Feng Yang*, Xiao-Long Yang*. New prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus Emericella sp. XL029 and their anti-agricultural pathogenic fungal and antibacterial activities. RSC Advances, 2017, 7, 31115-31122. (IF = 3.108, 2)

 [3] Dan Xu, Xue-Jiao Pang, Ting Zhao, Lu-Lin, Xiao-Long Yang*. New alkenylated tetrahydropyran derivatives from the marine sediment-derived fungus Westerdykella dispersa and their bioactivities. Fitoterapia, 2017, 122:45-51. (IF = 2.698, 3)

[4] Feng-Lou Liu, and Xiao-Long Yang*. Indole derivatives produced by the metagenome genes of the Escherichia coli-harboring marine sponge Discodermia calyx. Molecules, 2017, 22: 681. (IF = 2.861, 3)

[5] Xia Wu, Xue-Jiao Pang, Lu-Lin Xu, Qiong-Yin Zhang, Xin-Yu Long, Hai-Li Qin, Deng-Feng Yang*, Xiao-Long Yang*. Two new alkylated furan derivatives with antifungal and antibacterial activities from the plant endophytic fungus Emericella sp. XL029. Natural Product Research, 2017. (Published Online, doi: 10.1080/14786419.2017.1374269IF = 1.828, 4)

[6] Deng-Feng Yang, Feng-Lou Liu, Xiao-Long Yang*. DNA methyltransferase inhibitor dramatically alters the secondary metabolism of Pestalotiopsis microspore. Journal of Chinese Pharmaceutical Sciences, 2017, 26 (5):355-359.

[7] Dan Xu, Bing-Yang Zhang, Xiao-Long Yang*. Antifungal monoterpene derivatives from the plant   endophytic fungus Pestalotiopsis foedan. Chemistry & Biodiversity, 2016, 13: 1422-1425. (IF= 1.440, 4 )

[8] Xiao-Long Yang*, Le Huang, Hai-Ying Li, Deng-Feng Yang, Zhuangzhuang Li. Two new compounds from the plant endophytic fungus Pestalotiopsis versicolor. Journal of Asian Natural Products Research, 2015, 17(4):333-337. (IF = 1.071, 4)

[9] Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, and Ikuro Abe. Three acyltetronic acid derivatives: Noncanonical cryptic polyketides from Aspergillus niger identified by genome mining. ChemBioChem, 2014, 15:1578-1583. (IF = 2.847, 3)

 [10] Xiao-Long Yang*, Le Huang, Xiao-Li Ruan. Epigenetic modifiers alters the secondary metabolite composition of a plant endophytic fungus, Pestalotiopsis crassiuscula obtained from the leaves of Fragaria chiloensis. Journal of Asian Natural Products Research, 2014. 16(4):412-417. (IF = 1.071, 4)

 [11] Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, and Ikuro Abe. Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae. Tetrahedron Letters, 2013, 54: 5814-5817. (IF = 2.193, 3)

[12] Xiao-Long Yang, Toshiyuki Wakimoto, Yuya Takeshige, Rui He, Yoko Egami, Ikuro Abe. Indole-porphyrin hybrids produced by metagenomics. Bioorganic Medicinal Chemistry Letters, 2013, 23:3810-3813. (IF = 2.331, 3)

[13] Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, and Ikuro Abe. Induced production of the novel glycolipid ustilagic acid C in the plant pathogen Ustilago maydis. Tetrahedron Letters, 2013, 54:3655-3657. (IF = 2.391, 3)

[14] Xiao-Long Yang*, Zhuang-Zhuang Li. New spiral γ-lactone enantiomers from the plant endophytic fungus Pestalotiopsis foedan. Molecules, 2013, 18: 2236-2242. (IF = 2.095, 3)

[15] Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, and Ikuro Abe. Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum. Natural Products and Bioprospecting, 2013, 3, 141-144.

[16] Xiao-Long Yang*, Zhuang-Zhuang Li, Hai-Ying Li, Zhi-Qin Liu. Antifungal secondary metabolites from the plant endophytic fungus Pestalotiopsis photiniae isolated from the Chinese podocarpaceae plant Podocarpus macrophyllus. African Journal of Microbiology Research, 2013, 7 (27): 3563-3565.

[17] Takayoshi Awakawa, Xiao-Long Yang, Toshiyuki Wakimoto, and Ikuro Abe. Pyranonigrin E: A novel PKS-NRPS hybrid metabolite from Aspergillus niger identified by genome mining. ChemBioChem, 2013, 14: 2095-2099. (IF = 3.060, 3)

[18] Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo. The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus. Natural Product Reports, 2012, 29(6):622-641. (Cover article) (IF = 11.013, 1)

[19] Xiao-Long Yang*, Zhuang-Zhuang Li, Su Zhang, He Yu, Hua-Jie Zhu, Du-Qiang Luo. A new spirocyclic compound from the liquid culture of entomogenous fungus Isaria cateniannulata. Journal of Asian Natural Products Research, 2012, 14(11):1093-1096. (IF = 0.948, 4)

[20] Xiao-Long Yang, Su Zhang, Hua-Jie Zhu, Du-Qiang Luo, Xue-Yan Gao. Eremophilane-type sesquiterpenoids from the fermentation broth of plant endophytic fungus Pestalotiopsis photiniae isolated from the Chinese podocarpaceae plant Podocarpus macrophyllus. Helvetica Chimica Acta, 2011, 94, 1463-1469. (IF = 1.478, 4)

[21] Xiao-Long Yang*, Su Zhang, Hua-Jie Zhu, Du-Qiang Luo. Dihydroberkleasmin A: A new eremophilane sesquiterpenoid from the fermentation broth of plant endophytic fungus Pestalotiopsis photiniae. Molecules, 2011, 16, 1910-1916. (IF = 2.386, 3)

[22] Xiao-Long Yang, Su Zhang, Qiong-Bo Hu, Du-Qiang Luo, Yan Zhang. Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae. Journal of Antibiotics, 2011, 64, 723-727. (IF = 1.651, 4)

[23] Xiao-Long Yang, Zheng-Hong Xie, Xian-Jun Jiang, Yan-Bing Huang and Ji-Kai Liu. A new acridone alkaloid from Micromelum integerrimum. Chemical & Pharmaceutical Bulletin, 2009, 57(7), 734-735. (IF = 1.698, 4)

[24] Xiao-Long Yang, Cheng Qin, Fei Wang, Ze-Jun Dong, and Ji-Kai Liu. A new meroterpenoid pigment from the basidiomycete Albatrellus confluens. Chemistry & Biodiversity, 2008, 5 (3): 484-489. (IF = 1.659, 4)

[25] Xiao-Long Yang, Kun-Lung Hsieh, and Ji-Kai Liu. Guajadial: An unusual meroterpenoid from guava leaves Psidium guajava. Organic Letters, 2007, 9: 5135-5138. (IF = 6.579, 1)

[26] Xiao-Long Yang, Du-Qiang Luo, Ze-Jun Dong, Ji-Kai Liu. Two new pigments from the fruiting bodies of the basidiomycete Lactarius deliciosus. Helvetica Chimica Acta, 2006, 89: 988-990. (IF = 1.550, 4)

[27] Xiao-Long Yang, Du-Qiang Luo, and Ji-Kai Liu. A new pigment from fruiting bodies of the basidiomecete Lactarius deliciosus. Zeitschrift für Naturforschung B-A Journal of Chemical Sciences, 2006, 61:1180-1182. (IF = 0.825, 4)


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